EGF
EGF (Pro-epidermal growth factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
Overview
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.99, genetic association 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EGF (Pro-epidermal growth factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
- 1 · What it is
EGF (Pro-epidermal growth factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
- 2 · What goes wrong in cancer
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
- 3 · How drugs use it
No product in this corpus aims at EGF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3229 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01133 (protein name, function text, keywords and locations (REST API)); CIViC gene EGF (1 evidence items, 0 assertions, 1 variants; diseases: Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000138798 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Biology
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. Location: Membrane (UniProt). Locus 4q25 (HGNC).
- Head and neck squamous cell carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EGF" OR ABSTRACT:"EGF" OR TITLE:"epidermal growth factor" OR ABSTRACT:"epidermal growth factor" OR TITLE:"Pro-epidermal growth factor" OR ABSTRACT:"Pro-epidermal growth factor") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EGF, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetCBL
Shares Receptor tyrosine kinase activation, CIViC, Open Targets Platform.
- TargetSTAT3
Shares Receptor tyrosine kinase activation, CIViC, Open Targets Platform.
- TargetGRB2
Shares Receptor tyrosine kinase activation, Open Targets Platform.
- TargetHGF
Shares Receptor tyrosine kinase activation, CIViC, Open Targets Platform.