ERCC5
ERCC5 (DNA excision repair protein ERCC-5) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer, Skin cancer, Neuroendocrine tumours and 3 more.
Overview
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble.
CIViC holds 4 clinical evidence items and 0 assertions across 2 variants, naming Immune Checkpoint Inhibitor. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.97, animal model 0.57, genetic association 0.65, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ERCC5 (DNA excision repair protein ERCC-5) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer, Skin cancer, Neuroendocrine tumours and 3 more.
- 1 · What it is
ERCC5 (DNA excision repair protein ERCC-5) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer, Skin cancer, Neuroendocrine tumours and 3 more.
- 2 · What goes wrong in cancer
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER).
- 3 · How drugs use it
No product in this corpus aims at ERCC5 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:3437 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P28715 (protein name, function text, keywords and locations (REST API)); CIViC gene ERCC5 (4 evidence items, 0 assertions, 2 variants; diseases: Melanoma, Lung Non-small Cell Carcinoma, Parietal Lobe Ependymoma, Cancer (GraphQL API, CC0)); Open Targets ENSG00000134899 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: colorectal cancer 0.51, ovarian cancer 0.57, melanoma 0.54, neuroendocrine neoplasm 0.52, skin cancer 0.56 (GraphQL API, CC0))
Biology
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble. Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidised pyrimidines from DNA. Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognised stalled RNA polymerase II. Location: Nucleus; Chromosome (UniProt). Locus 13q33.1 (HGNC).
- Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170)
- Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)
- Neuroendocrine tumours: Open Targets association 0.52 with neuroendocrine neoplasm (MONDO_0019496)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
- Melanoma: Open Targets association 0.54 with melanoma (MONDO_0005105); CIViC evidence names this disease
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Parietal Lobe Ependymoma.
Latest papers
topQuery for this target: (TITLE:"ERCC5" OR ABSTRACT:"ERCC5" OR TITLE:"ERCC excision repair 5, endonuclease" OR ABSTRACT:"ERCC excision repair 5, endonuclease" OR TITLE:"DNA excision repair protein ERCC-5" OR ABSTRACT:"DNA excision repair protein ERCC-5" OR TITLE:"ERCM2" OR ABSTRACT:"ERCM2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERCC5, not a curated reading list.