FAM131B
FAM131B (family with sequence similarity 131 member B) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
UniProt has no function text for Q86XD5; HGNC names it "family with sequence similarity 131 member B".
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.12, affected pathway 0.89, genetic association 0.00, somatic mutation 0.49).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FAM131B (family with sequence similarity 131 member B) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
FAM131B (family with sequence similarity 131 member B) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
UniProt has no function text for Q86XD5; HGNC names it "family with sequence similarity 131 member B". Locus 7q34 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at FAM131B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:22202 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86XD5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000159784 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
UniProt has no function text for Q86XD5; HGNC names it "family with sequence similarity 131 member B". Locus 7q34 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FAM131B" OR ABSTRACT:"FAM131B" OR TITLE:"family with sequence similarity 131 member B" OR ABSTRACT:"family with sequence similarity 131 member B" OR TITLE:"KIAA0773" OR ABSTRACT:"KIAA0773") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAM131B, not a curated reading list.