FOS
FOS (Fos proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Overview
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signalling.
CIViC holds 3 clinical evidence items and 1 assertion across 2 variants, naming Irbesartan.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FOS (Fos proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 1 · What it is
FOS (Fos proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites.
- 3 · How drugs use it
No product in this corpus aims at FOS yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3796 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01100 (protein name, function text, keywords and locations (REST API)); CIViC gene FOS (3 evidence items, 1 assertions, 2 variants; diseases: Osteoblastoma, Colon Adenocarcinoma (GraphQL API, CC0))
Biology
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signalling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. Location: Nucleus; Endoplasmic reticulum; Cytoplasm, cytosol (UniProt). Locus 14q24.3 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Osteoblastoma.
Latest papers
topQuery for this target: (TITLE:"FOS" OR ABSTRACT:"FOS" OR TITLE:"Fos proto-oncogene, AP-1 transcription factor subunit" OR ABSTRACT:"Fos proto-oncogene, AP-1 transcription factor subunit" OR TITLE:"c-fos" OR ABSTRACT:"c-fos" OR TITLE:"AP-1" OR ABSTRACT:"AP-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOS, not a curated reading list.