FOXO4
FOXO4 (Forkhead box protein O4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
Transcription factor involved in the regulation of the insulin signalling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.89).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FOXO4 (Forkhead box protein O4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
FOXO4 (Forkhead box protein O4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Transcription factor involved in the regulation of the insulin signalling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.
- 3 · How drugs use it
No product in this corpus aims at FOXO4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7139 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P98177 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184481 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Transcription factor involved in the regulation of the insulin signalling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Location: Cytoplasm; Nucleus (UniProt). Locus Xq13.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FOXO4" OR ABSTRACT:"FOXO4" OR TITLE:"forkhead box O4" OR ABSTRACT:"forkhead box O4" OR TITLE:"Forkhead box protein O4" OR ABSTRACT:"Forkhead box protein O4" OR TITLE:"AFX1" OR ABSTRACT:"AFX1" OR TITLE:"MLLT7" OR ABSTRACT:"MLLT7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXO4, not a curated reading list.