GHSR
GHSR (Growth hormone secretagogue receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach. Upon activation, stimulates appetite and promotes growth hormone secretion. Ghrelin binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.16, clinical 0.92).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GHSR (Growth hormone secretagogue receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
GHSR (Growth hormone secretagogue receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach. Upon activation, stimulates appetite and promotes growth hormone secretion.
- 3 · How drugs use it
No product in this corpus aims at GHSR yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4267 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92847 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000121853 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Biology
G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach. Upon activation, stimulates appetite and promotes growth hormone secretion. Ghrelin binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. GHSR is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. Location: Cell membrane (UniProt). Locus 3q26.31 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.92. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GHSR" OR ABSTRACT:"GHSR" OR TITLE:"growth hormone secretagogue receptor" OR ABSTRACT:"growth hormone secretagogue receptor" OR TITLE:"Growth hormone secretagogue receptor type 1" OR ABSTRACT:"Growth hormone secretagogue receptor type 1" OR TITLE:"GHS-R1a" OR ABSTRACT:"GHS-R1a" OR TITLE:"GHS-R" OR ABSTRACT:"GHS-R" OR TITLE:"GHSR-1a" OR ABSTRACT:"GHSR-1a") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GHSR, not a curated reading list.