GREM1
GREM1 (Gremlin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signalling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro).
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.98, animal model 0.38, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GREM1 (Gremlin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
GREM1 (Gremlin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop.
- 3 · How drugs use it
No product in this corpus aims at GREM1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2001 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60565 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166923 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: colorectal cancer 0.56 (GraphQL API, CC0))
Biology
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signalling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. Location: Secreted (UniProt). Locus 15q13.3 (HGNC).
- Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GREM1" OR ABSTRACT:"GREM1" OR TITLE:"gremlin 1, DAN family BMP antagonist" OR ABSTRACT:"gremlin 1, DAN family BMP antagonist" OR TITLE:"Gremlin-1" OR ABSTRACT:"Gremlin-1" OR TITLE:"gremlin" OR ABSTRACT:"gremlin" OR TITLE:"DAND2" OR ABSTRACT:"DAND2" OR TITLE:"CKTSF1B1" OR ABSTRACT:"CKTSF1B1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GREM1, not a curated reading list.