Interferon alpha receptor (IFNAR1)
The receptor through which interferon alpha alerts immune cells and slows tumour growth. Interferon was one of the first immunotherapies, used in melanoma, hairy cell leukaemia and chronic myeloid leukaemia, and has largely given way to targeted drugs and checkpoint inhibitors.
Overview
IFNAR1 pairs with IFNAR2 to form the receptor for all type I interferons; binding activates JAK1 and TYK2 and the STAT1 and STAT2 transcription factors that induce antiviral, antiproliferative and immune-stimulating genes. Recombinant interferon alfa-2b was approved for hairy cell leukaemia in 1986, then for melanoma, follicular lymphoma, Kaposi sarcoma and chronic myeloid leukaemia, but flu-like symptoms, depression and modest benefit meant that cladribine, imatinib, rituximab and checkpoint inhibitors replaced it. Pegylated interferon remains useful in myeloproliferative neoplasms, and endogenous type I interferon signalling within tumours predicts response to immunotherapy.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · The receptor through which interferon alpha alerts immune cells and slows tumour growth. Interferon was one of the first immunotherapies, used in melanoma, hairy cell leukaemia and chronic myeloid leukaemia, and has largely given way to targeted drugs and checkpoint inhibitors.
- 1 · What it is
The receptor through which interferon alpha alerts immune cells and slows tumour growth. Interferon was one of the first immunotherapies, used in melanoma, hairy cell leukaemia and chronic myeloid leukaemia, and has largely given way to targeted drugs and checkpoint inhibitors.
- 2 · What goes wrong in cancer
Subunit of the type I interferon receptor signalling through JAK1, TYK2 and STAT1/STAT2 to induce interferon-stimulated genes.
- 3 · How drugs use it
No product in this corpus aims at Interferon alpha receptor (IFNAR1) yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Biology
Subunit of the type I interferon receptor signalling through JAK1, TYK2 and STAT1/STAT2 to induce interferon-stimulated genes.
- Immune and tumour cells broadly; historic indications in melanoma, hairy cell leukaemia, CML and Kaposi sarcoma
Latest papers
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