KCND3
KCND3 (A-type voltage-gated potassium channel KCND3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart. In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA).
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.17, animal model 0.48, genetic association 0.36, clinical 0.76).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KCND3 (A-type voltage-gated potassium channel KCND3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
KCND3 (A-type voltage-gated potassium channel KCND3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart.
- 3 · How drugs use it
No product in this corpus aims at KCND3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6239 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UK17 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171385 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Biology
Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart. In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA). Kinetics properties are characterised by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Location: Cell membrane; Cell membrane, sarcolemma; Cell projection, dendrite (UniProt). Locus 1p13.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KCND3" OR ABSTRACT:"KCND3" OR TITLE:"potassium voltage-gated channel subfamily D member 3" OR ABSTRACT:"potassium voltage-gated channel subfamily D member 3" OR TITLE:"A-type voltage-gated potassium channel KCND3" OR ABSTRACT:"A-type voltage-gated potassium channel KCND3" OR TITLE:"Kv4.3" OR ABSTRACT:"Kv4.3" OR TITLE:"KSHIVB" OR ABSTRACT:"KSHIVB" OR TITLE:"SCA22" OR ABSTRACT:"SCA22") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KCND3, not a curated reading list.