LIG4
LIG4 (DNA ligase 4) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Overview
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyses the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.88, animal model 0.51, genetic association 0.44, genetic literature 0.76).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LIG4 (DNA ligase 4) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 1 · What it is
LIG4 (DNA ligase 4) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination.
- 3 · How drugs use it
No product in this corpus aims at LIG4 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:6601 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49917 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000174405 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Biology
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyses the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Location: Nucleus (UniProt). Locus 13q33.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LIG4" OR ABSTRACT:"LIG4" OR TITLE:"DNA ligase 4" OR ABSTRACT:"DNA ligase 4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LIG4, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetRAD51
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
- TargetPOLK
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
- TargetCHEK2
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
- TargetPOLQ
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
- TargetATM
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.