LMNA
LMNA (Prelamin-A/C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organisation, nuclear membrane and telomere dynamics. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.88, genetic association 0.33, somatic mutation 0.49, animal model 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LMNA (Prelamin-A/C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
LMNA (Prelamin-A/C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane.
- 3 · How drugs use it
No product in this corpus aims at LMNA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6636 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02545 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000160789 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Biology
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organisation, nuclear membrane and telomere dynamics. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Lamin A and C are present in equal amounts in the lamina of mammals. Also involved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilising broken DNA ends. Location: Nucleus lamina; Nucleus envelope; Nucleus, nucleoplasm; Nucleus matrix (UniProt). Locus 1q22 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LMNA" OR ABSTRACT:"LMNA" OR TITLE:"lamin A/C" OR ABSTRACT:"lamin A/C" OR TITLE:"Prelamin-A/C" OR ABSTRACT:"Prelamin-A/C" OR TITLE:"LMN1" OR ABSTRACT:"LMN1" OR TITLE:"CMD1A" OR ABSTRACT:"CMD1A" OR TITLE:"LGMD1B" OR ABSTRACT:"LGMD1B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LMNA, not a curated reading list.