MMP2
MMP2 (72 kDa type IV collagenase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Bevacizumab. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 1.00, animal model 0.79, genetic association 0.56, clinical 0.66).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MMP2 (72 kDa type IV collagenase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
MMP2 (72 kDa type IV collagenase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture.
- 3 · How drugs use it
No product in this corpus aims at MMP2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:7166 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08253 (protein name, function text, keywords and locations (REST API)); CIViC gene MMP2 (2 evidence items, 0 assertions, 1 variants; diseases: Brain Glioma, Inflammatory Breast Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000087245 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumour invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Location: Secreted, extracellular space, extracellular matrix; Membrane; Nucleus; Cytoplasm (UniProt). Locus 16q12.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.66; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Brain Glioma; Inflammatory Breast Carcinoma.
Latest papers
topQuery for this target: (TITLE:"MMP2" OR ABSTRACT:"MMP2" OR TITLE:"matrix metallopeptidase 2" OR ABSTRACT:"matrix metallopeptidase 2" OR TITLE:"72 kDa type IV collagenase" OR ABSTRACT:"72 kDa type IV collagenase" OR TITLE:"MMP-2" OR ABSTRACT:"MMP-2" OR TITLE:"TBE-1" OR ABSTRACT:"TBE-1" OR TITLE:"CLG4" OR ABSTRACT:"CLG4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MMP2, not a curated reading list.