MT-ND1
MT-ND1 (NADH-ubiquinone oxidoreductase chain 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.55, clinical 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MT-ND1 (NADH-ubiquinone oxidoreductase chain 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
MT-ND1 (NADH-ubiquinone oxidoreductase chain 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
- 3 · How drugs use it
No product in this corpus aims at MT-ND1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7455 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P03886 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198888 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MT-ND1" OR ABSTRACT:"MT-ND1" OR TITLE:"mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1" OR ABSTRACT:"mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1" OR TITLE:"NADH-ubiquinone oxidoreductase chain 1" OR ABSTRACT:"NADH-ubiquinone oxidoreductase chain 1" OR TITLE:"ND1" OR ABSTRACT:"ND1" OR TITLE:"NAD1" OR ABSTRACT:"NAD1" OR TITLE:"MTND1" OR ABSTRACT:"MTND1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MT-ND1, not a curated reading list.