MUS81
MUS81 (Structure-specific endonuclease subunit MUS81) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Overview
Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability. Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Olaparib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MUS81 (Structure-specific endonuclease subunit MUS81) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
- 1 · What it is
MUS81 (Structure-specific endonuclease subunit MUS81) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
- 2 · What goes wrong in cancer
Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability.
- 3 · How drugs use it
No product in this corpus aims at MUS81 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:29814 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96NY9 (protein name, function text, keywords and locations (REST API)); CIViC gene MUS81 (1 evidence items, 0 assertions, 2 variants; diseases: Ovarian Cancer (GraphQL API, CC0))
Biology
Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability. Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing. Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. Location: Nucleus, nucleolus (UniProt). Locus 11q13 (HGNC).
- Ovarian cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MUS81" OR ABSTRACT:"MUS81" OR TITLE:"MUS81 structure-specific endonuclease subunit" OR ABSTRACT:"MUS81 structure-specific endonuclease subunit" OR TITLE:"Structure-specific endonuclease subunit MUS81" OR ABSTRACT:"Structure-specific endonuclease subunit MUS81" OR TITLE:"FLJ44872" OR ABSTRACT:"FLJ44872" OR TITLE:"SLX3" OR ABSTRACT:"SLX3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MUS81, not a curated reading list.