MYBL1
MYBL1 (Myb-related protein A) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Transcription factor that specifically recognises the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity.
CIViC holds 3 clinical evidence items and 1 assertion across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MYBL1 (Myb-related protein A) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
MYBL1 (Myb-related protein A) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Transcription factor that specifically recognises the sequence 5'-YAAC[GT]G-3'.
- 3 · How drugs use it
No product in this corpus aims at MYBL1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7547 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10243 (protein name, function text, keywords and locations (REST API)); CIViC gene MYBL1 (3 evidence items, 1 assertions, 1 variants; diseases: Diffuse Astrocytoma, MYB- Or MYBL1-altered (GraphQL API, CC0))
Biology
Transcription factor that specifically recognises the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Transcriptional activator of SOX30. Location: Nucleus (UniProt). Locus 8q13.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Diffuse Astrocytoma, MYB- Or MYBL1-altered.
Latest papers
topQuery for this target: (TITLE:"MYBL1" OR ABSTRACT:"MYBL1" OR TITLE:"MYB proto-oncogene like 1" OR ABSTRACT:"MYB proto-oncogene like 1" OR TITLE:"Myb-related protein A" OR ABSTRACT:"Myb-related protein A" OR TITLE:"A-myb" OR ABSTRACT:"A-myb") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYBL1, not a curated reading list.