NOTCH3
NOTCH3 (Neurogenic locus notch homolog protein 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Overview
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Tarextumab.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NOTCH3 (Neurogenic locus notch homolog protein 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
- 1 · What it is
NOTCH3 (Neurogenic locus notch homolog protein 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
- 2 · What goes wrong in cancer
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.
- 3 · How drugs use it
No product in this corpus aims at NOTCH3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7883 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UM47 (protein name, function text, keywords and locations (REST API)); CIViC gene NOTCH3 (2 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Cancer, Rectum Cancer (GraphQL API, CC0))
Biology
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Location: Cell membrane; Nucleus (UniProt). Locus 19p13.12 (HGNC).
- Pancreatic ductal adenocarcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Rectum Cancer.
Latest papers
topQuery for this target: (TITLE:"NOTCH3" OR ABSTRACT:"NOTCH3" OR TITLE:"notch receptor 3" OR ABSTRACT:"notch receptor 3" OR TITLE:"Neurogenic locus notch homolog protein 3" OR ABSTRACT:"Neurogenic locus notch homolog protein 3" OR TITLE:"CASIL" OR ABSTRACT:"CASIL" OR TITLE:"CADASIL" OR ABSTRACT:"CADASIL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NOTCH3, not a curated reading list.