NQO1
NQO1 (NAD(P)H dehydrogenase [quinone] 1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer and Pancreatic ductal adenocarcinoma.
Overview
Flavin-containing quinone reductase that catalyses two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species. Regulates cellular redox state primarily through quinone detoxification.
CIViC holds 3 clinical evidence items and 0 assertions across 3 variants, naming Amrubicin and NSC84167.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NQO1 (NAD(P)H dehydrogenase [quinone] 1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer and Pancreatic ductal adenocarcinoma.
- 1 · What it is
NQO1 (NAD(P)H dehydrogenase [quinone] 1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer and Pancreatic ductal adenocarcinoma.
- 2 · What goes wrong in cancer
Flavin-containing quinone reductase that catalyses two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors.
- 3 · How drugs use it
No product in this corpus aims at NQO1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:2874 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15559 (protein name, function text, keywords and locations (REST API)); CIViC gene NQO1 (3 evidence items, 0 assertions, 3 variants; diseases: Lung Cancer, Pancreatic Ductal Adenocarcinoma (GraphQL API, CC0))
Biology
Flavin-containing quinone reductase that catalyses two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species. Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion. Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential. Location: Cytoplasm, cytosol (UniProt). Locus 16q22.1 (HGNC).
- Lung cancer: CIViC evidence names this disease
- Pancreatic ductal adenocarcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NQO1" OR ABSTRACT:"NQO1" OR TITLE:"NAD P H quinone dehydrogenase 1" OR ABSTRACT:"NAD P H quinone dehydrogenase 1" OR TITLE:"NAD P H dehydrogenase [quinone] 1" OR ABSTRACT:"NAD P H dehydrogenase [quinone] 1" OR TITLE:"QR1" OR ABSTRACT:"QR1" OR TITLE:"NMOR1" OR ABSTRACT:"NMOR1" OR TITLE:"DIA4" OR ABSTRACT:"DIA4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NQO1, not a curated reading list.
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