NUDT15
NUDT15 (Nucleotide triphosphate diphosphatase NUDT15) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it.
Overview
Catalyses the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidised forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyse the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyses oxidised nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Mercaptopurine, Thioguanine and Azathioprine. In OnCo, 1 product record names it (Mercaptopurine).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NUDT15 (Nucleotide triphosphate diphosphatase NUDT15) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it.
- 1 · What it is
NUDT15 (Nucleotide triphosphate diphosphatase NUDT15) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Catalyses the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidised forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP.
- 3 · How drugs use it
No product in this corpus aims at NUDT15 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:23063 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NV35 (protein name, function text, keywords and locations (REST API)); CIViC gene NUDT15 (1 evidence items, 0 assertions, 1 variants; diseases: Childhood Acute Lymphocytic Leukaemia (GraphQL API, CC0))
Biology
Catalyses the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidised forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyse the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyses oxidised nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitising role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilising PCNA. Locus 13q14.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Childhood Acute Lymphocytic Leukaemia.
Latest papers
topQuery for this target: (TITLE:"NUDT15" OR ABSTRACT:"NUDT15" OR TITLE:"nudix hydrolase 15" OR ABSTRACT:"nudix hydrolase 15" OR TITLE:"Nucleotide triphosphate diphosphatase NUDT15" OR ABSTRACT:"Nucleotide triphosphate diphosphatase NUDT15" OR TITLE:"MTH2" OR ABSTRACT:"MTH2" OR TITLE:"FLJ10956" OR ABSTRACT:"FLJ10956") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUDT15, not a curated reading list.