OTX1
OTX1 (Homeobox protein OTX1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.93, animal model 0.57, genetic association 0.73).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · OTX1 (Homeobox protein OTX1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
OTX1 (Homeobox protein OTX1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
- 3 · How drugs use it
No product in this corpus aims at OTX1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:8521 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P32242 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115507 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: prostate cancer 0.56 (GraphQL API, CC0))
Biology
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Location: Nucleus (UniProt). Locus 2p15 (HGNC).
- Prostate cancer: Open Targets association 0.56 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"OTX1" OR ABSTRACT:"OTX1" OR TITLE:"orthodenticle homeobox 1" OR ABSTRACT:"orthodenticle homeobox 1" OR TITLE:"Homeobox protein OTX1" OR ABSTRACT:"Homeobox protein OTX1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OTX1, not a curated reading list.