PAX3
PAX3 (Paired box protein Pax-3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Rhabdomyosarcoma.
Overview
Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10.
Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes genetic literature 0.61, affected pathway 0.40, literature 0.96, genetic association 0.75, somatic mutation 0.98, animal model 0.57).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PAX3 (Paired box protein Pax-3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Rhabdomyosarcoma.
- 1 · What it is
PAX3 (Paired box protein Pax-3) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Rhabdomyosarcoma.
- 2 · What goes wrong in cancer
Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis.
- 3 · How drugs use it
No product in this corpus aims at PAX3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:8617 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P23760 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135903 (association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: sarcoma 0.77, rhabdomyosarcoma 0.74 (GraphQL API, CC0))
Biology
Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10. Location: Nucleus (UniProt). Locus 2q36.1 (HGNC).
- Sarcomas: Open Targets association 0.77 with sarcoma (MONDO_0005089)
- Rhabdomyosarcoma: Open Targets association 0.74 with rhabdomyosarcoma (MONDO_0005212)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PAX3" OR ABSTRACT:"PAX3" OR TITLE:"paired box 3" OR ABSTRACT:"paired box 3" OR TITLE:"Paired box protein Pax-3" OR ABSTRACT:"Paired box protein Pax-3" OR TITLE:"HUP2" OR ABSTRACT:"HUP2" OR TITLE:"PAX-3" OR ABSTRACT:"PAX-3" OR TITLE:"WS1" OR ABSTRACT:"WS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAX3, not a curated reading list.
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