PNPLA3
PNPLA3 (1-acylglycerol-3-phosphate O-acyltransferase PNPLA3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Hepatocellular carcinoma.
Overview
Specifically catalyses coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PNPLA3 (1-acylglycerol-3-phosphate O-acyltransferase PNPLA3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Hepatocellular carcinoma.
- 1 · What it is
PNPLA3 (1-acylglycerol-3-phosphate O-acyltransferase PNPLA3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Hepatocellular carcinoma.
- 2 · What goes wrong in cancer
Specifically catalyses coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids.
- 3 · How drugs use it
No product in this corpus aims at PNPLA3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:18590 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NST1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100344 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: hepatocellular carcinoma 0.52 (GraphQL API, CC0))
Biology
Specifically catalyses coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Location: Membrane; Lipid droplet (UniProt). Locus 22q13.31 (HGNC).
- Hepatocellular carcinoma: Open Targets association 0.52 with hepatocellular carcinoma (MONDO_0007256)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PNPLA3" OR ABSTRACT:"PNPLA3" OR TITLE:"patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase" OR ABSTRACT:"patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase" OR TITLE:"1-acylglycerol-3-phosphate O-acyltransferase PNPLA3" OR ABSTRACT:"1-acylglycerol-3-phosphate O-acyltransferase PNPLA3" OR TITLE:"dJ796I17.1" OR ABSTRACT:"dJ796I17.1" OR TITLE:"FLJ22012" OR ABSTRACT:"FLJ22012" OR TITLE:"adiponutrin" OR ABSTRACT:"adiponutrin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PNPLA3, not a curated reading list.