PRKACA
PRKACA (cAMP-dependent protein kinase catalytic subunit alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Hepatocellular carcinoma.
Overview
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP. Regulates the abundance of compartmentalised pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.00, somatic mutation 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PRKACA (cAMP-dependent protein kinase catalytic subunit alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Hepatocellular carcinoma.
- 1 · What it is
PRKACA (cAMP-dependent protein kinase catalytic subunit alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Hepatocellular carcinoma.
- 2 · What goes wrong in cancer
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP.
- 3 · How drugs use it
No product in this corpus aims at PRKACA yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:9380 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17612 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000072062 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: hepatocellular carcinoma 0.51 (GraphQL API, CC0))
Biology
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP. Regulates the abundance of compartmentalised pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in chondrogenesis by mediating phosphorylation of SOX9. Location: Cytoplasm; Cell membrane; Membrane; Nucleus (UniProt). Locus 19p13.12 (HGNC).
- Hepatocellular carcinoma: Open Targets association 0.51 with hepatocellular carcinoma (MONDO_0007256)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PRKACA" OR ABSTRACT:"PRKACA" OR TITLE:"protein kinase cAMP-activated catalytic subunit alpha" OR ABSTRACT:"protein kinase cAMP-activated catalytic subunit alpha" OR TITLE:"cAMP-dependent protein kinase catalytic subunit alpha" OR ABSTRACT:"cAMP-dependent protein kinase catalytic subunit alpha" OR TITLE:"PKACa" OR ABSTRACT:"PKACa") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PRKACA, not a curated reading list.