PTTG1
PTTG1 (Securin) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Meningioma.
Overview
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PTTG1 (Securin) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Meningioma.
- 1 · What it is
PTTG1 (Securin) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Meningioma.
- 2 · What goes wrong in cancer
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins.
- 3 · How drugs use it
No product in this corpus aims at PTTG1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9690 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95997 (protein name, function text, keywords and locations (REST API)); CIViC gene PTTG1 (1 evidence items, 0 assertions, 1 variants; diseases: Meningioma (GraphQL API, CC0))
Biology
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. Location: Cytoplasm; Nucleus (UniProt). Locus 5q33.3 (HGNC).
- Meningioma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PTTG1" OR ABSTRACT:"PTTG1" OR TITLE:"PTTG1 regulator of sister chromatid separation, securin" OR ABSTRACT:"PTTG1 regulator of sister chromatid separation, securin" OR TITLE:"Securin" OR ABSTRACT:"Securin" OR TITLE:"HPTTG" OR ABSTRACT:"HPTTG" OR TITLE:"EAP1" OR ABSTRACT:"EAP1" OR TITLE:"securin" OR ABSTRACT:"securin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTTG1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetLEPR
Shares Meningioma, CIViC.
- TargetSUFU
Shares Meningioma, CIViC.