RAD51B
RAD51B (DNA repair protein RAD51 homolog 2) is a gene. The public catalogues list it as a drug target, a biomarker, a fusion partner and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Prostate cancer, Ovarian cancer and 2 more.
Overview
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.87, genetic association 0.64, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RAD51B (DNA repair protein RAD51 homolog 2) is a gene. The public catalogues list it as a drug target, a biomarker, a fusion partner and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Prostate cancer, Ovarian cancer and 2 more.
- 1 · What it is
RAD51B (DNA repair protein RAD51 homolog 2) is a gene. The public catalogues list it as a drug target, a biomarker, a fusion partner and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Prostate cancer, Ovarian cancer and 2 more.
- 2 · What goes wrong in cancer
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments.
- 3 · How drugs use it
No product in this corpus aims at RAD51B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9822 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15315 (protein name, function text, keywords and locations (REST API)); CIViC gene RAD51B (2 evidence items, 0 assertions, 2 variants; diseases: Ovarian Cancer, Castration-resistant Prostate Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000182185 (association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: prostate cancer 0.52, ovarian cancer 0.56, skin cancer 0.52, breast cancer 0.68, lung cancer 0.54 (GraphQL API, CC0))
Biology
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. Location: Nucleus (UniProt). Locus 14q24.1 (HGNC).
- Breast cancer: Open Targets association 0.68 with breast cancer (MONDO_0007254)
- Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315); CIViC evidence names this disease
- Ovarian cancer: Open Targets association 0.56 with ovarian cancer (MONDO_0008170); CIViC evidence names this disease
- Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RAD51B" OR ABSTRACT:"RAD51B" OR TITLE:"RAD51 paralog B" OR ABSTRACT:"RAD51 paralog B" OR TITLE:"DNA repair protein RAD51 homolog 2" OR ABSTRACT:"DNA repair protein RAD51 homolog 2" OR TITLE:"REC2" OR ABSTRACT:"REC2" OR TITLE:"hREC2" OR ABSTRACT:"hREC2" OR TITLE:"R51H2" OR ABSTRACT:"R51H2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAD51B, not a curated reading list.
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