SCN11A
SCN11A (Sodium channel protein type 11 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarisation during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.20, genetic association 0.00, clinical 0.86).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SCN11A (Sodium channel protein type 11 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
SCN11A (Sodium channel protein type 11 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes.
- 3 · How drugs use it
No product in this corpus aims at SCN11A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10583 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UI33 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168356 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarisation during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarisation. Location: Cell membrane (UniProt). Locus 3p22.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SCN11A" OR ABSTRACT:"SCN11A" OR TITLE:"sodium voltage-gated channel alpha subunit 11" OR ABSTRACT:"sodium voltage-gated channel alpha subunit 11" OR TITLE:"Sodium channel protein type 11 subunit alpha" OR ABSTRACT:"Sodium channel protein type 11 subunit alpha" OR TITLE:"Nav1.9" OR ABSTRACT:"Nav1.9" OR TITLE:"NaN" OR ABSTRACT:"NaN" OR TITLE:"SNS-2" OR ABSTRACT:"SNS-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SCN11A, not a curated reading list.