SCN7A
SCN7A (Sodium channel protein type 7 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behaviour as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.70, genetic association 0.00, clinical 0.86).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SCN7A (Sodium channel protein type 7 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
SCN7A (Sodium channel protein type 7 subunit alpha) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient.
- 3 · How drugs use it
No product in this corpus aims at SCN7A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10594 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01118 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136546 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Biology
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behaviour as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body. By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis. Location: Cell membrane (UniProt). Locus 2q24.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SCN7A" OR ABSTRACT:"SCN7A" OR TITLE:"sodium voltage-gated channel alpha subunit 7" OR ABSTRACT:"sodium voltage-gated channel alpha subunit 7" OR TITLE:"Sodium channel protein type 7 subunit alpha" OR ABSTRACT:"Sodium channel protein type 7 subunit alpha" OR TITLE:"Nav2.1" OR ABSTRACT:"Nav2.1" OR TITLE:"Nav2.2" OR ABSTRACT:"Nav2.2" OR TITLE:"NaG" OR ABSTRACT:"NaG") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SCN7A, not a curated reading list.