SDHAF2
SDHAF2 (Succinate dehydrogenase assembly factor 2, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Ovarian cancer.
Overview
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes literature 0.79, genetic association 0.85, somatic mutation 0.95, genetic literature 0.81).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SDHAF2 (Succinate dehydrogenase assembly factor 2, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Ovarian cancer.
- 1 · What it is
SDHAF2 (Succinate dehydrogenase assembly factor 2, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Ovarian cancer.
- 2 · What goes wrong in cancer
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.
- 3 · How drugs use it
No product in this corpus aims at SDHAF2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:26034 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NX18 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167985 (association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: ovarian cancer 0.51, neuroendocrine neoplasm 0.83 (GraphQL API, CC0))
Biology
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. Location: Mitochondrion matrix (UniProt). Locus 11q12.2 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.83 with neuroendocrine neoplasm (MONDO_0019496)
- Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SDHAF2" OR ABSTRACT:"SDHAF2" OR TITLE:"succinate dehydrogenase complex assembly factor 2" OR ABSTRACT:"succinate dehydrogenase complex assembly factor 2" OR TITLE:"Succinate dehydrogenase assembly factor 2, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase assembly factor 2, mitochondrial" OR TITLE:"FLJ20487" OR ABSTRACT:"FLJ20487" OR TITLE:"SDH5" OR ABSTRACT:"SDH5" OR TITLE:"PGL2" OR ABSTRACT:"PGL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHAF2, not a curated reading list.