SLC6A4
SLC6A4 (Sodium-dependent serotonin transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signalling. Essential for serotonin homeostasis in the central nervous system.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.71, animal model 0.28, genetic association 0.00, clinical 0.83).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLC6A4 (Sodium-dependent serotonin transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
SLC6A4 (Sodium-dependent serotonin transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle.
- 3 · How drugs use it
No product in this corpus aims at SLC6A4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11050 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31645 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108576 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signalling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organisation of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signalling at the synapse. Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Location: Cell membrane; Endomembrane system; Endosome membrane; Synapse (UniProt). Locus 17q11.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.83. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLC6A4" OR ABSTRACT:"SLC6A4" OR TITLE:"solute carrier family 6 member 4" OR ABSTRACT:"solute carrier family 6 member 4" OR TITLE:"Sodium-dependent serotonin transporter" OR ABSTRACT:"Sodium-dependent serotonin transporter" OR TITLE:"5-HTT" OR ABSTRACT:"5-HTT" OR TITLE:"SERT1" OR ABSTRACT:"SERT1" OR TITLE:"OCD1" OR ABSTRACT:"OCD1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC6A4, not a curated reading list.