SLFN11
SLFN11 (Schlafen family member 11) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Ewing sarcoma and Small-cell lung cancer.
Overview
Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Temozolomide, 7-Ethyl-10-Hydroxycamptothecin, Talazoparib and Niraparib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLFN11 (Schlafen family member 11) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Ewing sarcoma and Small-cell lung cancer.
- 1 · What it is
SLFN11 (Schlafen family member 11) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Ewing sarcoma and Small-cell lung cancer.
- 2 · What goes wrong in cancer
Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication.
- 3 · How drugs use it
No product in this corpus aims at SLFN11 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:26633 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z7L1 (protein name, function text, keywords and locations (REST API)); CIViC gene SLFN11 (3 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer, Ewing Sarcoma, Lung Small Cell Carcinoma (GraphQL API, CC0))
Biology
Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signalling. Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease. A single tRNA molecule is bound and cleaved by the SLFN11 dimer. Location: Nucleus; Chromosome (UniProt). Locus 17q12 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
- Ewing sarcoma: CIViC evidence names this disease
- Small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA damage". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLFN11" OR ABSTRACT:"SLFN11" OR TITLE:"schlafen family member 11" OR ABSTRACT:"schlafen family member 11" OR TITLE:"Schlafen family member 11" OR ABSTRACT:"Schlafen family member 11" OR TITLE:"FLJ34922" OR ABSTRACT:"FLJ34922") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLFN11, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetPTPRD
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- TermAdolescent and young adult (AYA) oncology
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