TUBA1A
TUBA1A (Tubulin alpha-1A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
Overview
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.55, animal model 0.55, genetic association 0.00, clinical 1.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TUBA1A (Tubulin alpha-1A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
- 1 · What it is
TUBA1A (Tubulin alpha-1A chain) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more.
- 2 · What goes wrong in cancer
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.
- 3 · How drugs use it
No product in this corpus aims at TUBA1A yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:20766 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q71U36 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167552 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.61, gastric cancer 0.54, prostate cancer 0.59, ovarian cancer 0.57, cervical cancer 0.59, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0))
Biology
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, flagellum axoneme (UniProt). Locus 12q13.12 (HGNC).
- Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254)
- Lung cancer: Open Targets association 0.61 with lung cancer (MONDO_0008903)
- Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908)
- Prostate cancer: Open Targets association 0.59 with prostate cancer (MONDO_0008315)
- Hodgkin lymphoma: Open Targets association 0.59 with Hodgkins lymphoma (MONDO_0004952)
- Cervical cancer: Open Targets association 0.59 with cervical cancer (MONDO_0002974)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 1.00. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TUBA1A" OR ABSTRACT:"TUBA1A" OR TITLE:"tubulin alpha 1a" OR ABSTRACT:"tubulin alpha 1a" OR TITLE:"Tubulin alpha-1A chain" OR ABSTRACT:"Tubulin alpha-1A chain" OR TITLE:"TUBA3" OR ABSTRACT:"TUBA3" OR TITLE:"B-ALPHA-1" OR ABSTRACT:"B-ALPHA-1" OR TITLE:"FLJ25113" OR ABSTRACT:"FLJ25113") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBA1A, not a curated reading list.
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