VDR
VDR (Vitamin D3 receptor) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 1.00, animal model 0.55, genetic association 0.46, clinical 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · VDR (Vitamin D3 receptor) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
VDR (Vitamin D3 receptor) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR.
- 3 · How drugs use it
No product in this corpus aims at VDR yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:12679 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11473 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000111424 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites. Location: Nucleus; Cytoplasm (UniProt). Locus 12q13.11 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"VDR" OR ABSTRACT:"VDR" OR TITLE:"vitamin D receptor" OR ABSTRACT:"vitamin D receptor" OR TITLE:"Vitamin D3 receptor" OR ABSTRACT:"Vitamin D3 receptor" OR TITLE:"NR1I1" OR ABSTRACT:"NR1I1" OR TITLE:"PPP1R163" OR ABSTRACT:"PPP1R163") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VDR, not a curated reading list.