VTI1A
VTI1A (Vesicle transport through interaction with t-SNAREs homolog 1A) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.37, genetic association 0.60, somatic mutation 0.49).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · VTI1A (Vesicle transport through interaction with t-SNAREs homolog 1A) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
VTI1A (Vesicle transport through interaction with t-SNAREs homolog 1A) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane.
- 3 · How drugs use it
No product in this corpus aims at VTI1A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17792 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96AJ9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000151532 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Location: Cytoplasmic vesicle; Golgi apparatus membrane (UniProt). Locus 10q25.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"VTI1A" OR ABSTRACT:"VTI1A" OR TITLE:"vesicle transport through interaction with t-SNAREs 1A" OR ABSTRACT:"vesicle transport through interaction with t-SNAREs 1A" OR TITLE:"Vesicle transport through interaction with t-SNAREs homolog 1A" OR ABSTRACT:"Vesicle transport through interaction with t-SNAREs homolog 1A" OR TITLE:"MVti1" OR ABSTRACT:"MVti1" OR TITLE:"Vti1-rp2" OR ABSTRACT:"Vti1-rp2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VTI1A, not a curated reading list.