WDCP
WDCP (WD repeat and coiled-coil-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
UniProt has no function text for Q9H6R7; HGNC names it "WD repeat and coiled coil containing".
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.08, affected pathway 0.76, genetic association 0.00, somatic mutation 0.65).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · WDCP (WD repeat and coiled-coil-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
WDCP (WD repeat and coiled-coil-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
UniProt has no function text for Q9H6R7; HGNC names it "WD repeat and coiled coil containing". Locus 2p23.3 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at WDCP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:26157 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H6R7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163026 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
UniProt has no function text for Q9H6R7; HGNC names it "WD repeat and coiled coil containing". Locus 2p23.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"WDCP" OR ABSTRACT:"WDCP" OR TITLE:"WD repeat and coiled coil containing" OR ABSTRACT:"WD repeat and coiled coil containing" OR TITLE:"WD repeat and coiled-coil-containing protein" OR ABSTRACT:"WD repeat and coiled-coil-containing protein" OR TITLE:"FLJ21945" OR ABSTRACT:"FLJ21945" OR TITLE:"C2orf44" OR ABSTRACT:"C2orf44") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WDCP, not a curated reading list.