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Coenzyme Q10 is an antioxidant supplement sold for heart health and energy. Studies in cancer fatigue are mixed, and in a breast cancer study women who took it before and during chemotherapy had a higher risk of the cancer coming back, so it is one to stop during treatment unless the team agrees.
Coenzyme Q10 is made in every cell and has a role in mitochondrial energy production; as a supplement it is promoted for heart disease, statin muscle pain, migraine and cancer. Memorial Sloan Kettering's About Herbs summary reports that studies of whether it helps cancer-related fatigue are mixed, that findings on reducing treatment toxicity conflict, and that supplementation before and during treatment was associated with a higher hazard of recurrence in women with breast cancer. That association, from a study of supplement use in a chemotherapy trial, is observational, but it points the same way as the wider concern that antioxidants may blunt chemotherapy and radiotherapy; in a mouse model of lung cancer, ubiquinone reduced the effect of radiotherapy. The NCI PDQ summary on coenzyme Q10 gives the background history and the earlier small uncontrolled reports. Interactions listed by MSK: it resembles vitamin K and may weaken warfarin, although increased bleeding has also been reported with warfarin, and it slows clearance of theophylline. Side effects are infrequent and mild (nausea, diarrhoea, poor appetite).
An electron carrier in the mitochondrial respiratory chain and a lipid antioxidant; the antioxidant action that is the selling point is also the reason for concern during treatments that work partly through oxidative damage.
Query for this technology: (TITLE:"Coenzyme Q10" OR ABSTRACT:"Coenzyme Q10" OR TITLE:"CoQ10" OR ABSTRACT:"CoQ10" OR TITLE:"Ubiquinone" OR ABSTRACT:"Ubiquinone" OR TITLE:"Ubiquinol" OR ABSTRACT:"Ubiquinol") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Coenzyme Q10, not a curated reading list.
Shares Fatigue after cancer treatment: what actually works, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Milk thistle (silymarin), Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued, HR-positive / HER2-negative breast cancer and the tags complementary, supportive-care.
Shares Fatigue after cancer treatment: what actually works, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Fatigue after cancer treatment: what actually works, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued, HR-positive / HER2-negative breast cancer and the tags complementary, supportive-care.
Shares Milk thistle (silymarin), Evidence-based integrative oncology, Toxicity and quality of life are undervalued, HR-positive / HER2-negative breast cancer and the tags complementary, supportive-care.
Shares Fatigue after cancer treatment: what actually works, Evidence-based integrative oncology, Toxicity and quality of life are undervalued, HR-positive / HER2-negative breast cancer and the tags complementary, supportive-care.
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