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Resveratrol, found in red grape skins, is sold as an anti-ageing and anti-cancer supplement because it lengthened the life of yeast cells. That has never been shown in people. A trial of a high-dose form in myeloma was stopped because of serious side effects including kidney failure, and it has oestrogen-like effects that are a concern in hormone-sensitive cancers.
Memorial Sloan Kettering's About Herbs entry describes resveratrol as a polyphenol marketed for anti-ageing on the strength of yeast lifespan studies, an effect not demonstrated in humans. Trials in people show no benefit on cognition, cardiovascular risk factors, insulin sensitivity or all-cause mortality in older adults, and a Cochrane review found insufficient evidence in diabetes. Laboratory work suggests antiproliferative, radiomodulating and chemotherapy-potentiating effects, but data in cancer patients are limited to phase 1 pilot studies in colorectal cancer. A study of a high-dose micronised formulation in multiple myeloma was stopped because of serious adverse events including renal failure. At concentrations similar to those needed for its other effects, resveratrol activates oestrogen and androgen receptor transcription and can stimulate cancer cell proliferation, so MSK advises caution in hormone-sensitive cancers. At 1 g a day for four weeks it inhibited CYP3A4, 2D6 and 2C9 and induced 1A2 in healthy volunteers, which can change levels of many drugs, including oral cancer drugs; it also inhibits platelet aggregation. High doses of 2.5 to 5 g a day cause diarrhoea.
A sirtuin-activating and antioxidant polyphenol in laboratory models; poorly bioavailable, with oestrogen-receptor activity at achievable concentrations.
Query for this technology: (TITLE:"Resveratrol supplements" OR ABSTRACT:"Resveratrol supplements" OR TITLE:"Resveratrol" OR ABSTRACT:"Resveratrol" OR TITLE:"trans-resveratrol" OR ABSTRACT:"trans-resveratrol" OR TITLE:"Polygonum cuspidatum extract" OR ABSTRACT:"Polygonum cuspidatum extract") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Resveratrol supplements, not a curated reading list.
Shares Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
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Shares Green tea and EGCG extracts, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Green tea and EGCG extracts, Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
Shares Unproven diet claims (alkaline, juice, 'anti-cancer' diets), Dietary supplements during cancer treatment: interactions and harms, Evidence-based integrative oncology, Misinformation and unproven therapies and the tags complementary, supportive-care.
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