Erythromelalgia
Burning pain, redness and heat in the hands or feet, brought on by warmth. In polycythaemia vera and essential thrombocythaemia it comes from platelets clumping in tiny vessels and often disappears with low-dose aspirin.
Overview
Erythromelalgia in the myeloproliferative neoplasms is a microvascular symptom caused by activated platelets blocking small arterioles in the extremities. Its hallmark is rapid relief with aspirin, which is one reason low-dose aspirin is part of PV treatment for almost everyone. Persistent symptoms call for cytoreduction to lower the platelet count.
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