termsTerm
Squamous cell carcinoma vs adenocarcinoma of the oesophagus
Oesophageal cancer is two different diseases in one organ: squamous cell carcinoma (upper/mid oesophagus, tobacco and alcohol, dominant in Asia) and adenocarcinoma (lower oesophagus, reflux and obesity, dominant in the West).
ESCC is ~85% of cases worldwide, concentrated in the 'oesophageal cancer belt' from Iran to China; genetically resembles head-and-neck squamous cancer (TP53, NOTCH1, CCND1, SOX2) and responds better to chemoradiation and immunotherapy. EAC arises from Barrett's, resembles gastric adenocarcinoma (HER2 amplification in ~15-20%), and is treated on gastric-like pathways (FLOT, trastuzumab, zolbetuximab trials). Trial eligibility, PD-L1 scoring (TAP vs CPS), and surgery differ between them.
Pathology: what this kind of term is about · animated schematic, not to scale
Category
Pathology