termsTerm
High-grade serous ovarian carcinoma (HGSOC)
High-grade serous ovarian carcinoma is the most common and most lethal type of ovarian cancer; it actually starts in the fallopian tube and almost always has a broken TP53 gene.
About 70% of ovarian cancer deaths. Near-universal TP53 mutation, ~50% homologous recombination deficiency (including ~20% BRCA1/2), extensive copy-number instability, few recurrent targetable mutations. Arises from serous tubal intraepithelial carcinoma, which is why opportunistic salpingectomy prevents it. PARP inhibitors, platinum, and FRα ADCs are the main therapeutic levers.
Cancer biology: what this kind of term is about · animated schematic, not to scale
Category
Cancer biology