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Abnormal cells lining prostate ducts that are not cancer and are not treated. On its own it is a finding, not a diagnosis; what matters is whether it is widespread and whether anything more atypical was seen beside it.
High-grade prostatic intraepithelial neoplasia is an abnormal proliferation of the cells lining prostatic ducts and acini, with the basal cell layer still present. It is a recognised precursor lesion and it has its own morphological code in the UK reporting dataset, but it is not cancer, it is not staged and it is not treated. Isolated HGPIN on a biopsy in the era of MRI-targeted sampling carries a low enough risk of a cancer being found on a repeat biopsy that it does not by itself trigger one.
What changed in the WHO fifth edition is the boundary above it. Lesions with more atypia than HGPIN but not enough for intraductal carcinoma are now called atypical intraductal proliferation, and what used to be reported as cribriform high-grade PIN has moved into that category, because the carcinomas found beside atypical intraductal proliferation behave like those found beside intraductal carcinoma. So the three-step ladder a reader may meet on a report runs HGPIN, then atypical intraductal proliferation, then intraductal carcinoma of the prostate, and only the last two change what happens next.
About three quarters of cancers arise in the peripheral zone at the back of the gland, the part a finger or a biopsy needle reaches; drainage is to the obturator and iliac nodes.
Same organ: Ductal adenocarcinoma of the prostate, Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Localised prostate cancer, high and very high risk, Biochemical recurrence of prostate cancer, Metastatic hormone-sensitive prostate cancer, Non-metastatic castration-resistant prostate cancer, Metastatic castration-resistant prostate cancer, Neuroendocrine and small-cell prostate cancer
Showing the organ this term concerns: Prostate cancer.
Shares Cribriform growth pattern in prostate cancer, Intraductal carcinoma of the prostate (IDC-P), Prostate cancer.
Shares Cribriform growth pattern in prostate cancer, Intraductal carcinoma of the prostate (IDC-P), Prostate cancer.
Shares Cribriform growth pattern in prostate cancer, Dysplasia (pre-cancerous change), Prostate cancer.
Shares Cribriform growth pattern in prostate cancer, Intraductal carcinoma of the prostate (IDC-P), Prostate cancer.
Shares Intraductal carcinoma of the prostate (IDC-P), Prostate cancer.
Shares Carcinoma in situ (CIS), Dysplasia (pre-cancerous change).
Shares Cribriform growth pattern in prostate cancer, Intraductal carcinoma of the prostate (IDC-P), Prostate cancer.
Shares Intraductal carcinoma of the prostate (IDC-P), Prostate cancer.