termsTerm
Low-grade serous ovarian cancer (LGSOC)
Low-grade serous ovarian cancer is a slow-growing, RAS-driven type of ovarian cancer that resists chemotherapy but responds to hormone blockers and MEK-pathway drugs.
About 5-10% of serous ovarian cancers; younger patients, KRAS/BRAF/NRAS mutations in ~30-50%, wild-type TP53, strong ER expression, low proliferation. Chemotherapy response rates are under 25%; endocrine therapy and MEK/RAF pathway inhibition (trametinib in GOG 281; avutometinib + defactinib, approved 2025) are the mainstays. Contrast with high-grade serous carcinoma.
Cancer biology: what this kind of term is about · animated schematic, not to scale
Category
Cancer biology