Loading
A virus passed mostly from mother to child in breast milk, common in parts of Japan, the Caribbean, west Africa and South America. Most people who carry it never become ill, but in a few it causes an aggressive T-cell cancer decades later.
Human T-lymphotropic virus 1 integrates into the DNA of a CD4 T cell and stays there. Two of its genes matter. Tax switches on NF-kB and interferes with the DNA damage response and the spindle checkpoint, which is how the infected clone starts to expand and to accumulate damage; it is also the most visible protein to the immune system, so clones that silence it survive. HBZ, encoded on the opposite DNA strand, is kept on when Tax is switched off and sustains proliferation more quietly.
What the host genome then acquires is not random. Across 426 cases analysed by whole-genome, exome, transcriptome and targeted sequencing with copy-number and methylation arrays, the alterations overlapped significantly with the set of proteins Tax itself binds, and were concentrated in T-cell receptor and NF-kB signalling, T-cell trafficking and immune surveillance: activating mutations in PLCG1, PRKCB, CARD11, VAV1, IRF4, FYN, CCR4 and CCR7, CTLA4-CD28 and ICOS-CD28 fusions, and intragenic deletions of IKZF2, CARD11 and TP73 (Kataoka 2015). The virus, in other words, starts the process and the cell finishes it along the lines the virus drew.
The practical consequence is CCR4. It is both frequently expressed and frequently mutated in this disease, and mogamulizumab, the anti-CCR4 antibody, is used because of it. The virus itself is not a drug target and antiviral treatment does not cure the leukaemia. Transmission is mainly through breastfeeding, and the interval between infection in infancy and the disease is measured in decades, which is why screening and formula feeding in endemic regions is a prevention question rather than a treatment one.
In plain words · CCR4 is a chemokine receptor on skin-homing and regulatory T cells, and on the malignant cells of cutaneous T-cell lymphoma and adult T-cell leukaemia; mogamulizumab removes those cells.
Showing the target this term concerns: CCR4.
Shares Epstein-Barr virus latency programmes, and why they decide which lymphoma, Oncogenic viruses, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).
Shares CD52, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).
Shares Epstein-Barr virus latency programmes, and why they decide which lymphoma, Oncogenic viruses, Inflammation & NF-κB, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).
Shares CCR4, CD52, Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).
Shares Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).
Shares Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).
Shares Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).
Shares Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma), Non-Hodgkin lymphoma (all types).