Oligoprogression

When only one or two spots grow on an otherwise working targeted therapy; treat the spots and keep the pill.

Local ablative therapy (SBRT, surgery) to the progressing lesions with continuation of the TKI extends time on effective systemic therapy in ALK- and EGFR-driven NSCLC. Distinct from oligometastatic disease at diagnosis.

Clinical: what this kind of term is about · animated schematic, not to scale