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Bone in the jaw that was in the path of radiotherapy for a head and neck cancer can lose its blood supply and break down, sometimes years later and often after a tooth is taken out. Dental treatment before radiotherapy and careful dental care afterwards lower the risk.
The ISOO-MASCC-ASCO guideline (2024) addresses osteoradionecrosis of the jaw secondary to head and neck radiotherapy. From a systematic review of 80 studies, the panel rated its recommendations on best practices for prevention and on surgical management as evidence-based with strong evidence, relied on informal consensus elsewhere, made no recommendation on leukocyte- and platelet-rich fibrin or photobiomodulation for prevention, and judged hyperbaric oxygen for prevention or management largely unjustified. NCI PDQ (Oral Complications of Cancer Therapies) sets out the dental assessment before high-dose head and neck radiotherapy, scheduled as early as possible so that any extractions can heal before treatment, and lists monitoring for osteoradionecrosis among the follow-up tasks. Medication-related osteonecrosis of the jaw is defined to exclude people who have had radiotherapy to the jaws.
Shares Late effects and survivorship toxicity and the tag supportive-care-gaps-2026-11.
Shares Late effects and survivorship toxicity, Head and neck squamous cell carcinoma.
Shares Late effects and survivorship toxicity, Head and neck squamous cell carcinoma.
Shares Late effects and survivorship toxicity, Head and neck squamous cell carcinoma.
Shares Late effects and survivorship toxicity, Head and neck squamous cell carcinoma.
Shares Radiotherapy, Late effects and survivorship toxicity.
Shares Radiotherapy, Late effects and survivorship toxicity.
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