Perineural invasion (PNI)
Cancer cells growing along the sheath of a nerve. Nerves act as tracks for spread, so this finding predicts recurrence, especially in pancreatic, prostate and head and neck cancers.
Nearly universal in pancreatic cancer (explaining its pain and local recurrence), common in prostate cancer biopsies and in cutaneous squamous and salivary cancers, PNI is an adverse pathological feature that can trigger adjuvant radiotherapy or wider margins. Biologically, nerves and tumours signal to each other (adrenergic and cholinergic signalling drive proliferation), which underpins the cancer neuroscience field and trials of beta-blockers and denervation. It is recorded in nearly every pathology report as present or absent.
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not linked directly; found by shared links- InstitutionGunma University Heavy Ion Medical Center
Shares Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Prostate cancer.
- IdeaCut the nerve supply to tumours with old drugs
Shares Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Prostate cancer.
- TermWhipple procedure (pancreaticoduodenectomy)
Shares Resection margins (R0 / R1 / R2), Pancreatic ductal adenocarcinoma.
- InstitutionQST Hospital (National Institutes for Quantum Science and Technology)
Shares Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Prostate cancer.
- PersonDeborah Watkins Bruner
Shares Head and neck squamous cell carcinoma, Prostate cancer.
- InstitutionApollo Hospitals (Apollo Cancer Centres)
Shares Head and neck squamous cell carcinoma, Prostate cancer.
- InstitutionHokkaido University Hospital
Shares Head and neck squamous cell carcinoma, Prostate cancer.
- TermResectable, borderline resectable and unresectable
Shares Resection margins (R0 / R1 / R2), Pancreatic ductal adenocarcinoma.