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A virtual cell is a computer model of a cell that predicts what happens when a gene is knocked out or a drug is added, letting researchers run perturbation experiments in software before the laboratory.
A cellular model or virtual cell is a computational model of aspects of a biological cell for in silico research (Wikipedia). The Arc Institute's Virtual Cell Challenge scores models on predicting expression after unseen genetic perturbations, and the Chan Zuckerberg Biohub's Virtual Cells platform hosts models, data and benchmarks for the field. Noetik's OCTO-vc applies a masked-token spatial single-cell transformer to proprietary tumour data for the same purpose. Whether a model recovers known biology (the right pathway for a known drug) is the first test of any in-silico screen, and a screen that returns nothing for mutation-driven drugs is behaving correctly, not failing.
Showing the technology this term belongs to: CRISPR functional genomics.
Shares Single-cell RNA sequencing (scRNA-seq, 10x Chromium), Foundation model, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Mechanism-of-action recovery and known-biology probes, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Mechanism-of-action recovery and known-biology probes, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Benchmarks, leaderboards and contamination, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Foundation model, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Single-cell RNA sequencing (scRNA-seq, 10x Chromium), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Single-cell RNA sequencing (scRNA-seq, 10x Chromium), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Benchmarks, leaderboards and contamination, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.