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A phase 2 trial of carboplatin, durvalumab, gemcitabine, nab-paclitaxel and other drugs in triple-negative breast cancer, run by National Cancer Institute (NCI), now recruiting.
Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer is a phase 2, randomised interventional study registered as NCT03606967 by National Cancer Institute (NCI), with a registry enrolment figure of 86 participants, started 2021-04-13 and due to reach its primary completion in 2026-12-30. Interventions recorded: Biopsy Procedure; Biospecimen Collection; Carboplatin; Computed Tomography; Durvalumab; Gemcitabine Hydrochloride; Magnetic Resonance Imaging; Nab-paclitaxel; Personalized Synthetic Long Peptide Vaccine; Poly ICLC; Sacituzumab Govitecan; Tremelimumab. Conditions listed: Anatomic Stage IV Breast Cancer AJCC v8; Invasive Breast Carcinoma; Metastatic Triple-Negative Breast Carcinoma. Triple-negative eligibility wording from the registry: "* Patients must have a histologically confirmed diagnosis of metastatic invasive triple negative breast cancer". Sites: United States. No results are recorded here; the registry entry is the source.
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