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A phase 2 trial of fruquintinib and fOLFIRI (5-FU, leucovorin, irinotecan) in colorectal cancer, run by SCRI Development Innovations, LLC, now recruiting.
A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL) is a phase 2, interventional study registered as NCT07011576 by SCRI Development Innovations, LLC, with a registry enrolment figure of 60 participants, started 2025-09-29 and due to reach its primary completion in 2027-01. Interventions recorded: fruquintinib; FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin). Conditions listed: Colon Cancer; Rectal Cancer; Colorectal Cancer; Colorectal Cancer (CRC). Primary outcome: Progression-Free Survival (PFS) rate at 6 months. Colorectal eligibility wording from the registry: "* Confirmed mCRC ; histologically documented adenocarcinoma of the colon or rectum with at least one measurable lesion according to RECIST v1". Sites: United States. No results are recorded here; the registry entry is the source.
Shares Fruquintinib, FOLFIRI (5-FU, leucovorin, irinotecan), Anti-angiogenic therapy, Topoisomerase-I inhibitors (and ADC payloads) and the tag colorectal-deep-dive.
Shares FOLFIRI (5-FU, leucovorin, irinotecan), Anti-angiogenic therapy, Topoisomerase-I inhibitors (and ADC payloads), Colon cancer (adenocarcinoma of the colon) and the tag colorectal-deep-dive.
Shares Fruquintinib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Fruquintinib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Fruquintinib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Fruquintinib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Fruquintinib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Fruquintinib, Anti-angiogenic therapy, Colon cancer (adenocarcinoma of the colon), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.