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A phase 2 trial of sintilimab and cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, now recruiting.
Optimizing Immunotherapy Combined With Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT07040098 by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, with a registry enrolment figure of 228 participants, started 2025-06-01 and due to reach its primary completion in 2027-06-30. Interventions recorded: Sintilimab; Short-course radiotherapy; Long-course concurrent chemoradiotherapy; CAPOX. Conditions listed: Locally Advanced Rectal Cancer (LARC). Primary outcome: Rate of complete response. Colorectal eligibility wording from the registry: "Pathologically confirmed rectal adenocarcinoma with immunohistochemical results indicating pMMR (proficient mismatch repair) or genetic testing confirming MSS (microsatellite stability);". Sites: China. No results are recorded here; the registry entry is the source.
Shares Sintilimab, CAPOX (capecitabine, oxaliplatin), Mismatch-repair deficient (MSI-high) colorectal cancer, Platinum agents and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Mismatch-repair deficient (MSI-high) colorectal cancer, Platinum agents, IMRT / IGRT (modern external beam) and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Platinum agents, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.