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A phase 2 trial of irinotecan (and liposomal irinotecan), tislelizumab and capecitabine in colorectal cancer, run by Affiliated Cancer Hospital of Shantou University Medical College, now recruiting.
Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Tislelizumab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement is a phase 2, interventional study registered as NCT07104604 by Affiliated Cancer Hospital of Shantou University Medical College, with a registry enrolment figure of 51 participants, started 2025-10-20 and due to reach its primary completion in 2027-03-31. Interventions recorded: Liposomal Irinotecan+Tislelizumab+Capecitabine+Rradiotherapy. Conditions listed: Rectal Cancer. Primary outcome: Complete response (CR) rate. Colorectal eligibility wording from the registry: "* Biopsy-confirmed pMMR (proficient mismatch repair) localized advanced low rectal adenocarcinoma (tumor's lower edge ≤ 10 cm from the anus)". Sites: China. No results are recorded here; the registry entry is the source.
Shares Irinotecan (and liposomal irinotecan), Topoisomerase-I inhibitors (and ADC payloads), Capecitabine, IMRT / IGRT (modern external beam) and the tag colorectal-deep-dive.
Shares Tislelizumab, Capecitabine, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Tislelizumab, Capecitabine, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Tislelizumab, Capecitabine, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Tislelizumab, Capecitabine, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Capecitabine, IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Tislelizumab, Topoisomerase-I inhibitors (and ADC payloads), IMRT / IGRT (modern external beam), Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Irinotecan (and liposomal irinotecan), Topoisomerase-I inhibitors (and ADC payloads), Capecitabine, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.