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Cancers
Multisystem Langerhans cell histiocytosis (with or without risk-organ involvement)
Data

Cancers·Multisystem Langerhans cell histiocytosis (with or without risk-organ involvement)

DataMultisystem Langerhans cell histiocytosis (with or without risk-organ involvement)

Back to the Multisystem Langerhans cell histiocytosis hub →26 connected records

Every connected record, the notes, the JSON, Markdown and RDF twins, and where the record came from and when it was checked.

Overview What it is Finding it Treating it Evidence The science Where you are Living with it What is coming Data

Data

Related pages

26

Direct links plus the targets, companies, and technologies of this cancer's products.

Similar pages

not linked directly; found by shared links

Cancer
Low-risk neuroblastoma (INRG very low and low risk, including stage MS)
Shares Late effects and survivorship toxicity, Ultrasound, MRI and the tags subtype-page, paediatric.
Cancer
Intermediate-risk neuroblastoma
Shares Late effects and survivorship toxicity, MRI, Cytotoxic chemotherapy and the tags subtype-page, paediatric.
Cancer
Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like or BCR::ABL1-like ALL)
Shares Allogeneic stem cell transplantation, Small-molecule kinase inhibitors and the tags subtype-page, paediatric.
Cancer
Acute myeloid leukaemia in children
Shares Late effects and survivorship toxicity, Allogeneic stem cell transplantation and the tags subtype-page, paediatric.
Cancer
Philadelphia chromosome-positive acute lymphoblastic leukaemia in children (Ph-positive ALL)
Shares Allogeneic stem cell transplantation, Small-molecule kinase inhibitors and the tags subtype-page, paediatric.
Cancer
High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL)
Shares Allogeneic stem cell transplantation, Cytotoxic chemotherapy and the tags subtype-page, paediatric.
Cancer
Infant acute lymphoblastic leukaemia (KMT2A-rearranged, under one year)
Shares Allogeneic stem cell transplantation and the tags subtype-page, paediatric.
Cancer
Relapsed and refractory acute lymphoblastic leukaemia in children
Shares Allogeneic stem cell transplantation and the tags subtype-page, paediatric.

technologies

8

Allogeneic stem cell transplantation Cytotoxic chemotherapy Histopathology & immunohistochemistry Liquid biopsy (ctDNA)MRI Small-molecule kinase inhibitors Survivorship care and late-effects surveillance Ultrasound

targets

1

drugs

5

ApprovedPurine nucleoside analogue

Cladribine · Leustatin / Litak

ApprovedSmall-molecule kinase inhibitor (MEK1/2)

Cobimetinib · Cotellic

ApprovedSmall-molecule kinase inhibitors (BRAF + MEK)

Dabrafenib + trametinib · Tafinlar + Mekinist

ApprovedSmall-molecule kinase inhibitor (BRAF V600)

Vemurafenib · Zelboraf

ApprovedVinca alkaloid (microtubule inhibitor)

Vinblastine · Velban

companies

4

Eli Lilly (incl. Loxo)Johnson & Johnson Novartis Roche / Genentech

pathways

1

RAS / RAF / MEK / ERK (MAPK)

terms

3

BRAF V600E mutation Cytopenias and myelosuppression Late effects and survivorship toxicity

trials

1

key papers

3

LCH-III: therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis Recurrent BRAF mutations in Langerhans cell histiocytosis Vemurafenib for refractory multisystem Langerhans cell histiocytosis in children: an international observational study

Machine-readable versions

The same record for scripts and assistants; checked 2026-09-18. Data CC BY-NC 4.0, attribute “Data from OnCo (onco.cc)”.

JSON with neighbours Markdown context RDF Turtle Sections with routes and counts API root

Not yet reviewedNeeds expert (clinical) and patient advocate review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Key papers for the 39 rare-cancer subtype pages · diff · file

Wikipedia

Langerhans cell histiocytosis

Sources & links

LCH-III (Blood 2013)
NCI PDQ Langerhans cell histiocytosis
Wikipedia

subtype-page paediatric

Data

JSON · ·

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Machine-readable versions of Multisystem Langerhans cell histiocytosis (with or without risk-organ involvement)

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id lch-multisystem.

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